A comparison of disk diffusion method and E-test in determining the susceptibility and resistance of <i>Klebsiella</i> and <i>Acinetobacter</i> strains to cefepime in patients with ventilator-associated pneumonia admitted to the intensive care unit

Introduction: Ventilator-associated pneumonia (VAP) which is mostly caused by microorganisms such as Acinetobacter and Klebsiella one of the causes death among patients in intensive care unit (ICU). Objectives: The aim this study was to compare disk diffusion method E-test detecting susceptibility strains isolated from lung secretions with VAP admitted ICU treated cefepime. Patients Methods: In cross-sectional descriptive study, 100 including 55 45 cases infected Klebsiella, respectively, according antibiogram participated. resistance cefepime determined using E-test. addition, kappa test used determine sensitivity specificity compared Results: were 100% 25%, respectively its positive predictive value 87.5% negative 100%. coefficient 0.35 (P&lt;0.0001), indicates a significant agreement between two tests. Conclusion: Disk has high low comparison determining ICU.